View source for 6scl


==Cryo-EM Structure of Barley Yellow Dwarf Virus VLP==
<SX load='6scl' size='340' side='right' viewer='molstar' caption='[[6scl]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6scl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Barley_yellow_dwarf_virus Barley yellow dwarf virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SCL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6scl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6scl OCA], [https://pdbe.org/6scl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6scl RCSB], [https://www.ebi.ac.uk/pdbsum/6scl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6scl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O56812_9TOMB O56812_9TOMB] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Luteoviridae are pathogenic plant viruses responsible for significant crop losses worldwide. They infect a wide range of food crops, including cereals, legumes, cucurbits, sugar beet, sugarcane, and potato and, as such, are a major threat to global food security. Viral replication is strictly limited to the plant vasculature, and this phloem limitation, coupled with the need for aphid transmission of virus particles, has made it difficult to generate virus in the quantities needed for high-resolution structural studies. Here, we exploit recent advances in heterologous expression in plants to produce sufficient quantities of virus-like particles for structural studies. We have determined their structures to high resolution by cryoelectron microscopy, providing the molecular-level insight required to rationally interrogate luteovirid capsid formation and aphid transmission, thereby providing a platform for the development of preventive agrochemicals for this important family of plant viruses.

Combining Transient Expression and Cryo-EM to Obtain High-Resolution Structures of Luteovirid Particles.,Byrne MJ, Steele JFC, Hesketh EL, Walden M, Thompson RF, Lomonossoff GP, Ranson NA Structure. 2019 Oct 8. pii: S0969-2126(19)30316-8. doi:, 10.1016/j.str.2019.09.010. PMID:31611039<ref>PMID:31611039</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6scl" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</SX>
[[Category: Barley yellow dwarf virus]]
[[Category: Large Structures]]
[[Category: Byrne MJ]]
[[Category: Ranson NA]]