View source for 6sga


==Body domain of the mt-SSU assemblosome from Trypanosoma brucei==
<SX load='6sga' size='340' side='right' viewer='molstar' caption='[[6sga]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6sga]] is a 72 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SGA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PM8:S-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL)+DECANETHIOATE'>PM8</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UBD:URIDINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>UBD</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sga OCA], [http://pdbe.org/6sga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sga RCSB], [http://www.ebi.ac.uk/pdbsum/6sga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sga ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q57WW9_TRYB2 Q57WW9_TRYB2]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU000722] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mitochondrial ribosomes (mitoribosomes) are large ribonucleoprotein complexes that synthesize proteins encoded by the mitochondrial genome. An extensive cellular machinery responsible for ribosome assembly has been described only for eukaryotic cytosolic ribosomes. Here we report that the assembly of the small mitoribosomal subunit in Trypanosoma brucei involves a large number of factors and proceeds through the formation of assembly intermediates, which we analyzed by using cryo-electron microscopy. One of them is a 4-megadalton complex, referred to as the small subunit assemblosome, in which we identified 34 factors that interact with immature ribosomal RNA (rRNA) and recognize its functionally important regions. The assembly proceeds through large-scale conformational changes in rRNA coupled with successive incorporation of mitoribosomal proteins, providing an example for the complexity of the ribosomal assembly process in mitochondria.

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.,Saurer M, Ramrath DJF, Niemann M, Calderaro S, Prange C, Mattei S, Scaiola A, Leitner A, Bieri P, Horn EK, Leibundgut M, Boehringer D, Schneider A, Ban N Science. 2019 Sep 13;365(6458):1144-1149. doi: 10.1126/science.aaw5570. PMID:31515389<ref>PMID:31515389</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6sga" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
== References ==
<references/>
__TOC__
</SX>
[[Category: Large Structures]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Ban, N]]
[[Category: Bieri, P]]
[[Category: Boehringer, D]]
[[Category: Calderaro, S]]
[[Category: Horn, E K]]
[[Category: Leibundgut, M]]
[[Category: Leitner, A]]
[[Category: Mattei, S]]
[[Category: Niemann, M]]
[[Category: Prange, C]]
[[Category: Ramrath, D J.F]]
[[Category: Saurer, M]]
[[Category: Scaiola, A]]
[[Category: Schneider, A]]
[[Category: Assembly intermediate]]
[[Category: Mitochondrial ribosome]]
[[Category: Ribosome]]
[[Category: Translation]]