View source for 6shl


==Structure of a marine algae virus of the order Picornavirales==
<SX load='6shl' size='340' side='right' viewer='molstar' caption='[[6shl]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6shl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetoceros_tenuissimus_RNA_virus_type-II Chaetoceros tenuissimus RNA virus type-II]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SHL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6shl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6shl OCA], [https://pdbe.org/6shl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6shl RCSB], [https://www.ebi.ac.uk/pdbsum/6shl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6shl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0B6VJB4_9VIRU A0A0B6VJB4_9VIRU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The order Picornavirales includes viruses that infect different kinds of eukaryotes and that share similar properties. The capsid proteins (CPs) of viruses in the order that infect unicellular organisms, such as algae, presumably possess certain characteristics that have changed little over the course of evolution, and thus these viruses may resemble the Picornavirales ancestor in some respects. Herein, we present the capsid structure of Chaetoceros tenuissimus RNA virus type II (CtenRNAV-II) determined using cryo-electron microscopy at a resolution of 3.1 A, the first of an algae virus belonging to the family Marnaviridae of the order Picornavirales A structural comparison to related invertebrate and vertebrate viruses revealed a unique surface loop of the major CP VP1 that had not been observed previously, and further, that another VP1 loop obscures the so-called canyon, which is a host-receptor binding site for many of the mammalian Picornavirales viruses. VP2 has an N-terminal tail, which has previously been reported as a primordial feature of Picornavirales viruses. Based on the above-mentioned and other critical structural features, the acquired traits among Picornavirales viruses were categorized for profound discussions. The observations afford new insights on three long-standing theories among Picornavirales: the canyon hypothesis, the primordial VP2 domain swap, and the hypothesis that algae picorna-like viruses could share characteristics with the Picornavirales ancestor.ImportanceIdentifying the acquired structural traits in virus capsids is important for elucidating what functions are essential among viruses that infect different hosts. The Picornavirales viruses infect a broad spectrum of hosts, ranging from unicellular algae to insects and mammals, and include many human pathogens. Those viruses that infect unicellular protists, such as algae, are likely to have undergone fewer structural changes during the course of evolution compared to those viruses that infect multicellular eukaryotes, and thus still share some characteristics with the Picornavirales ancestor. This manuscript describes the first atomic capsid structure of an alga Marnavirus, CtenRNAV-II. A comparison to capsid structures of the related invertebrate and vertebrate viruses identified a number of structural traits that have been functionally acquired or lost during the course of evolution. These observations provide new insights on past theories on the viability and evolution of Picornavirales viruses.

Capsid structure of a marine algae virus of the order Picornavirales.,Munke A, Kimura K, Tomaru Y, Okamoto K J Virol. 2020 Feb 5. pii: JVI.01855-19. doi: 10.1128/JVI.01855-19. PMID:32024776<ref>PMID:32024776</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6shl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</SX>
[[Category: Chaetoceros tenuissimus RNA virus type-II]]
[[Category: Large Structures]]
[[Category: Kimura K]]
[[Category: Munke A]]
[[Category: Okamoto K]]
[[Category: Tomaru Y]]