View source for 6slz


==Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist==
<StructureSection load='6slz' size='340' side='right'caption='[[6slz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6slz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SLZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LK8:(2~{S})-1-[2,4-bis(chloranyl)-3-[[2-methyl-4-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]carbonyl-~{N}-methyl-pyrrolidine-2-carboxamide'>LK8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6slz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slz OCA], [https://pdbe.org/6slz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6slz RCSB], [https://www.ebi.ac.uk/pdbsum/6slz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6slz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Amaudrut J]]
[[Category: Argiriadi MA]]
[[Category: Barth M]]
[[Category: Breinlinger EC]]
[[Category: Calderwood DJ]]
[[Category: Cusack KP]]
[[Category: Kort ME]]
[[Category: Montalbetti C]]
[[Category: Potin D]]
[[Category: Poupardin O]]
[[Category: Spitzer L]]