View source for 6ssm


==Human endogenous retrovirus (HML2) mature capsid assembly, T=3 icosahedron==
<SX load='6ssm' size='340' side='right' viewer='molstar' caption='[[6ssm]], [[Resolution|resolution]] 4.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ssm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SSM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.34&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ssm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssm OCA], [https://pdbe.org/6ssm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ssm RCSB], [https://www.ebi.ac.uk/pdbsum/6ssm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssm ProSAT]</span></td></tr>
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== Publication Abstract from PubMed ==
The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. Many maintain intact open reading frames and provirus expression together with HML2 particle formation are observed in early stage human embryo development and are associated with pluripotency as well as inflammatory disease, cancers and HIV-1 infection. Here, we reconstruct the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ single particle cryogenic electron microscopy (cryo-EM) to determine structures of four classes of CA Fullerene shell assemblies. These icosahedral and capsular assemblies reveal at high-resolution the molecular interactions that allow CA to form both pentamers and hexamers and show how invariant pentamers and structurally plastic hexamers associate to form the unique polyhedral structures found in retroviral cores.

Structural basis for Fullerene geometry in a human endogenous retrovirus capsid.,Acton O, Grant T, Nicastro G, Ball NJ, Goldstone DC, Robertson LE, Sader K, Nans A, Ramos A, Stoye JP, Taylor IA, Rosenthal PB Nat Commun. 2019 Dec 20;10(1):5822. doi: 10.1038/s41467-019-13786-y. PMID:31862888<ref>PMID:31862888</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
== References ==
<references/>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Acton OJH]]
[[Category: Rosenthal PB]]
[[Category: Taylor IA]]