View source for 6tda


==Structure of SWI/SNF chromatin remodeler RSC bound to a nucleosome==
<StructureSection load='6tda' size='340' side='right'caption='[[6tda]], [[Resolution|resolution]] 15.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6tda]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TDA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tda OCA], [https://pdbe.org/6tda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tda RCSB], [https://www.ebi.ac.uk/pdbsum/6tda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tda ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

==See Also==
*[[Actin-related protein 3D structures|Actin-related protein 3D structures]]
*[[Helicase 3D structures|Helicase 3D structures]]
*[[Histone 3D structures|Histone 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Synthetic construct]]
[[Category: Xenopus laevis]]
[[Category: Cramer P]]
[[Category: Dienemann C]]
[[Category: Stuetzer A]]
[[Category: Tegunov D]]
[[Category: Urlaub H]]
[[Category: Wagner FR]]
[[Category: Wang H]]