View source for 6tdx


==Cryo-EM structure of Euglena gracilis mitochondrial ATP synthase, rotor, rotational state 1==
<SX load='6tdx' size='340' side='right' viewer='molstar' caption='[[6tdx]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6tdx]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Euglena_gracilis Euglena gracilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TDX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tdx OCA], [https://pdbe.org/6tdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tdx RCSB], [https://www.ebi.ac.uk/pdbsum/6tdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tdx ProSAT]</span></td></tr>
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== Publication Abstract from PubMed ==
The mitochondrial ATP synthase fuels eukaryotic cells with chemical energy. Here we report the cryo-EM structure of a divergent ATP synthase dimer from mitochondria of Euglena gracilis, a member of the phylum Euglenozoa that also includes human parasites. It features 29 different subunits, 8 of which are newly identified. The membrane region was determined to 2.8 A resolution, enabling the identification of 37 associated lipids, including 25 cardiolipins, which provides insight into protein-lipid interaction and their functional roles. The rotor-stator interface comprises four membrane-embedded horizontal helices, including a distinct subunit a. The dimer interface is formed entirely by phylum-specific components, and a peripherally associated subcomplex contributes to the membrane curvature. The central and peripheral stalks directly interact with each other. Last, the ATPase inhibitory factor 1 (IF1) binds in a mode that is different from human, but conserved in Trypanosomatids.

Structure of a mitochondrial ATP synthase with bound native cardiolipin.,Muhleip A, McComas SE, Amunts A Elife. 2019 Nov 18;8. pii: 51179. doi: 10.7554/eLife.51179. PMID:31738165<ref>PMID:31738165</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
*[[ATPase 3D structures|ATPase 3D structures]]
== References ==
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[[Category: Euglena gracilis]]
[[Category: Large Structures]]
[[Category: Amunts A]]
[[Category: Muhleip A]]