View source for 6tju


==X-ray structure of C-terminal domain of human T-cell lymphotropic virus type 1 (HTLV-1)==
<StructureSection load='6tju' size='340' side='right'caption='[[6tju]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6tju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TJU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tju OCA], [https://pdbe.org/6tju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tju RCSB], [https://www.ebi.ac.uk/pdbsum/6tju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tju ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A1Y1CAU9_9DELA A0A1Y1CAU9_9DELA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus and the most oncogenic pathogen. Many of the ~20 million HTLV-1 infected people will develop severe leukaemia or an ALS-like motor disease, unless a therapy becomes available. A key step in the establishment of infection is the integration of viral genetic material into the host genome, catalysed by the retroviral integrase (IN) enzyme. Here, we use X-ray crystallography and single-particle cryo-electron microscopy to determine the structure of the functional deltaretroviral IN assembled on viral DNA ends and bound to the B56gamma subunit of its human host factor, protein phosphatase 2 A. The structure reveals a tetrameric IN assembly bound to two molecules of the phosphatase via a conserved short linear motif. Insight into the deltaretroviral intasome and its interaction with the host will be crucial for understanding the pattern of integration events in infected individuals and therefore bears important clinical implications.

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.,Barski MS, Minnell JJ, Hodakova Z, Pye VE, Nans A, Cherepanov P, Maertens GN Nat Commun. 2020 Oct 7;11(1):5043. doi: 10.1038/s41467-020-18874-y. PMID:33028863<ref>PMID:33028863</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6tju" style="background-color:#fffaf0;"></div>

==See Also==
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Human T-cell leukemia virus type I]]
[[Category: Large Structures]]
[[Category: Barski M]]
[[Category: Maertens GN]]