View source for 6uca


==Crystal structure of human ZCCHC4 in complex with SAH==
<StructureSection load='6uca' size='340' side='right'caption='[[6uca]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6uca]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UCA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.103&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uca OCA], [https://pdbe.org/6uca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uca RCSB], [https://www.ebi.ac.uk/pdbsum/6uca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uca ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZCHC4_HUMAN ZCHC4_HUMAN] rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910).<ref>PMID:30531910</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gao L]]
[[Category: Huang MJ]]
[[Category: Li DX]]
[[Category: Lu JW]]
[[Category: Ren WD]]
[[Category: Song J]]
[[Category: Wang GG]]