View source for 6ucc


==Structure of human PACRG-MEIG1 complex (limited proteolysis)==
<StructureSection load='6ucc' size='340' side='right'caption='[[6ucc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ucc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UCC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ucc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ucc OCA], [https://pdbe.org/6ucc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ucc RCSB], [https://www.ebi.ac.uk/pdbsum/6ucc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ucc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PACRG_HUMAN PACRG_HUMAN] Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.<ref>PMID:14532270</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Croteau N]]
[[Category: Khan N]]
[[Category: Pelletier D]]
[[Category: Trempe JF]]
[[Category: Veyron S]]