View source for 6uch


==SMARCB1 nucleosome-interacting C-terminal alpha helix==
<StructureSection load='6uch' size='340' side='right'caption='[[6uch]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6uch]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UCH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uch OCA], [https://pdbe.org/6uch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uch RCSB], [https://www.ebi.ac.uk/pdbsum/6uch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uch ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN] Neurofibromatosis type 3;Atypical teratoid rhabdoid tumor;Familial rhabdoid tumor;Familial multiple meningioma;Coffin-Siris syndrome. The disease is caused by mutations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN] Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.<ref>PMID:10078207</ref> <ref>PMID:12226744</ref> <ref>PMID:14604992</ref> <ref>PMID:16267391</ref> <ref>PMID:16314535</ref> <ref>PMID:9448295</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dhe-Paganon S]]
[[Category: Kadoch C]]
[[Category: Mashtalir N]]
[[Category: Seo HS]]
[[Category: Sun ZYJ]]
[[Category: Valencia AM]]
[[Category: Vangos HS]]
[[Category: Yeoh ZC]]