View source for 6ueb


==Structure of Rabies SAD-B19 L-P complex from cryo-EM==
<SX load='6ueb' size='340' side='right' viewer='molstar' caption='[[6ueb]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ueb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabies_virus_SAD_B19 Rabies virus SAD B19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UEB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ueb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ueb OCA], [https://pdbe.org/6ueb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ueb RCSB], [https://www.ebi.ac.uk/pdbsum/6ueb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ueb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHOSP_RABVS PHOSP_RABVS] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity). Inhibits interferon induction pathways by interacting with host TBK1 and preventing the formation of dynamic cytoplasmic condensates that have liquid properties and that are essential for interferon production (PubMed:36640307).<ref>PMID:15557246</ref> <ref>PMID:36640307</ref> 
== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Rabies virus SAD B19]]
[[Category: Harrison SC]]
[[Category: Horwitz JA]]