View source for 6um2


==Structure of M-6-P/IGFII Receptor and IGFII complex==
<SX load='6um2' size='340' side='right' viewer='molstar' caption='[[6um2]], [[Resolution|resolution]] 4.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6um2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UM2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.32&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6um2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6um2 OCA], [https://pdbe.org/6um2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6um2 RCSB], [https://www.ebi.ac.uk/pdbsum/6um2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6um2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

==See Also==
*[[Insulin-like growth factor|Insulin-like growth factor]]
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[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li X]]
[[Category: Qi X]]
[[Category: Wang R]]