View source for 6uqt


==Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors==
<StructureSection load='6uqt' size='340' side='right'caption='[[6uqt]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6uqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UQT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=QFS:2-hydroxyethyloxy-(3-methoxyphenyl)borinic+acid'>QFS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uqt OCA], [https://pdbe.org/6uqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uqt RCSB], [https://www.ebi.ac.uk/pdbsum/6uqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uqt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMPC_PSEAE AMPC_PSEAE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
High throughput screening for beta-lactamase inhibitors afforded biphenyl hits such as 1. Hit confirmation and X-ray soaking experiments with Pseudomonas Aeruginosa AmpC enzyme led to the identification of an aryl boronic acid-serine complex 4, which was formed from phenyl boronic acid 8 (an impurity in compound 1) and ethylene glycol (the cryoprotectant in the soaking experiment).

Serendipitous discovery of aryl boronic acids as beta-lactamase inhibitors.,Yang SW, Pan J, Root Y, Scapin G, Xiao L, Su J Bioorg Med Chem Lett. 2019 Nov 9:126795. doi: 10.1016/j.bmcl.2019.126795. PMID:31759850<ref>PMID:31759850</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6uqt" style="background-color:#fffaf0;"></div>

==See Also==
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Scapin G]]