View source for 6ura


==Crystal structure of RUBISCO from Promineofilum breve==
<StructureSection load='6ura' size='340' side='right'caption='[[6ura]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ura]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Promineofilum_breve Candidatus Promineofilum breve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6URA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6URA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAP:2-CARBOXYARABINITOL-1,5-DIPHOSPHATE'>CAP</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ura FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ura OCA], [https://pdbe.org/6ura PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ura RCSB], [https://www.ebi.ac.uk/pdbsum/6ura PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ura ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A160T9D2_9CHLR A0A160T9D2_9CHLR] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Rubisco sustains the biosphere through the fixation of CO2 into biomass. In plants and cyanobacteria, form I Rubisco is structurally comprised of large and small subunits, whereas all other Rubisco forms lack small subunits. The rise of the form I complex through the innovation of small subunits represents a key, yet poorly understood, transition in Rubisco's evolution. Through metagenomic analyses, we discovered a previously uncharacterized clade sister to form I Rubisco that evolved without small subunits. This clade diverged before the evolution of cyanobacteria and the origin of the small subunit; thus, it provides a unique reference point to advance our understanding of form I Rubisco evolution. Structural and kinetic data presented here reveal how a proto-form I Rubisco assembled and functioned without the structural stability imparted from small subunits. Our findings provide insight into a key evolutionary transition of the most abundant enzyme on Earth and the predominant entry point for nearly all global organic carbon.

Novel bacterial clade reveals origin of form I Rubisco.,Banda DM, Pereira JH, Liu AK, Orr DJ, Hammel M, He C, Parry MAJ, Carmo-Silva E, Adams PD, Banfield JF, Shih PM Nat Plants. 2020 Sep;6(9):1158-1166. doi: 10.1038/s41477-020-00762-4. Epub 2020, Aug 31. PMID:32868887<ref>PMID:32868887</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ura" style="background-color:#fffaf0;"></div>

==See Also==
*[[RuBisCO 3D structures|RuBisCO 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Candidatus Promineofilum breve]]
[[Category: Large Structures]]
[[Category: Adams PD]]
[[Category: Banda DM]]
[[Category: Liu AK]]
[[Category: Pereira JH]]
[[Category: Shih PM]]