View source for 6uzb


==Anthrax toxin protective antigen channels bound to edema factor==
<SX load='6uzb' size='340' side='right' viewer='molstar' caption='[[6uzb]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6uzb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UZB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uzb OCA], [https://pdbe.org/6uzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uzb RCSB], [https://www.ebi.ac.uk/pdbsum/6uzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uzb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.

==See Also==
*[[3D Adenylyl cyclase 3D structures|3D Adenylyl cyclase 3D structures]]
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[[Category: Bacillus anthracis]]
[[Category: Large Structures]]
[[Category: Hardenbrook NJ]]
[[Category: Krantz BA]]
[[Category: Liu S]]
[[Category: Zhou K]]
[[Category: Zhou ZH]]