View source for 6vcd


==Cryo-EM structure of IRP2-FBXL5-SKP1 complex==
<StructureSection load='6vcd' size='340' side='right'caption='[[6vcd]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6vcd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VCD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vcd OCA], [https://pdbe.org/6vcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vcd RCSB], [https://www.ebi.ac.uk/pdbsum/6vcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vcd ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IREB2_HUMAN IREB2_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/IREB2_HUMAN IREB2_HUMAN] RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.<ref>PMID:7983023</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Shi H]]
[[Category: Wang H]]
[[Category: Zheng N]]