View source for 6vkz


==Crystal Structure of the N-prenyltransferase DabA in Complex with GSPP and Mg2+==
<StructureSection load='6vkz' size='340' side='right'caption='[[6vkz]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6vkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudo-nitzschia_multiseries Pseudo-nitzschia multiseries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VKZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GST:GERANYL+S-THIOLODIPHOSPHATE'>GST</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vkz OCA], [https://pdbe.org/6vkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vkz RCSB], [https://www.ebi.ac.uk/pdbsum/6vkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vkz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DABA_PSEMU DABA_PSEMU] Magnesium-dependent glutamate N-prenyltransferase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP) (PubMed:30262498). Catalyzes the conversion of L-glutamic acid (L-Glu) to N-geranyl-L-glutamic acid (NGG) in the presence of geranyl diphosphate (GPP) (PubMed:30262498, PubMed:32457155). Also able to catalyze the formation of farnesyl-L-glutamate from farnesyl diphosphate (FPP) (PubMed:32457155). Cannot use dimethylallyl diphosphate (DMAPP) as substrate (PubMed:32457155).<ref>PMID:30262498</ref> <ref>PMID:32457155</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudo-nitzschia multiseries]]
[[Category: Chekan JR]]
[[Category: Moore BS]]
[[Category: Noel JP]]