View source for 6vm6


==Structure of Acinetobacter baumannii Cap4 SAVED/CARF-domain containing receptor with the cyclic trinucleotide 2'3'3'-cAAA==
<StructureSection load='6vm6' size='340' side='right'caption='[[6vm6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6vm6]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_sp._ATCC_27244 Acinetobacter sp. ATCC 27244] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VM6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vm6 OCA], [https://pdbe.org/6vm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vm6 RCSB], [https://www.ebi.ac.uk/pdbsum/6vm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vm6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAP4_ACIS2 CAP4_ACIS2] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type II-C(AAAA) CBASS system (PubMed:32839535).<ref>PMID:32839535</ref> <ref>PMID:32544385</ref>   Binds cyclic nucleotide second messengers (synthesized by CdnD, the cognate CD-NTase in the CBASS operon). Ligand binding activates it to endonucleolytically degrade dsDNA to approximately 6 bp length fragments, with a preference for 5'-C or 5'-G cleavage site. The minor product of CdnD is the activating nucleotide; also binds the major product (2',3',3'-cyclic AMP-AMP-AMP) but is not activated by it. Only binds DNA in the presence of ligand. Is not activated by c-di-AMP, c-di-GMP, 3'3'-cyclic GMP-AMP (3'3'-cGAMP) or 3',3',3'-cyclic AMP-AMP-GMP.<ref>PMID:32544385</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Acinetobacter sp. ATCC 27244]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Antine SP]]
[[Category: Cabrera V]]
[[Category: Keszei AFA]]
[[Category: Kranzusch PJ]]
[[Category: Lee ASY]]
[[Category: Lowey B]]
[[Category: Mekalanos JJ]]
[[Category: Morehouse BR]]
[[Category: Schwede F]]
[[Category: Shao S]]
[[Category: Whiteley AT]]