View source for 6vrd


==Crystal structure of RNase H/RNA/PS-ASO complex at an atomic level==
<StructureSection load='6vrd' size='340' side='right'caption='[[6vrd]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6vrd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VRD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.299&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6NW:2-O-METHYL-5-O-THIOPHOSPHONOADENOSINE'>6NW</scene>, <scene name='pdbligand=6OO:2-O-METHYL-5-O-THIOPHOSPHONOCYTIDINE'>6OO</scene>, <scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=AS:2-DEOXY-ADENOSINE+-5-THIO-MONOPHOSPHATE'>AS</scene>, <scene name='pdbligand=C5L:2-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>C5L</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=N7X:5-O-[(R)-hydroxy(sulfanylidene)-lambda~5~-phosphanyl]-2-O-(2-methoxyethyl)-5-methylcytidine'>N7X</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PST:THYMIDINE-5-THIOPHOSPHATE'>PST</scene>, <scene name='pdbligand=RFJ:2-O-methyl-5-O-thiophosphonoguanosine'>RFJ</scene>, <scene name='pdbligand=SC:2-DEOXY-CYTIDINE-5-THIOPHOSPHORATE'>SC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T39:2-O-METHOXYETHYLENE+THYMIDINE+5-MONOPHOSPHATE'>T39</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vrd OCA], [https://pdbe.org/6vrd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vrd RCSB], [https://www.ebi.ac.uk/pdbsum/6vrd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vrd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RNH1_HUMAN RNH1_HUMAN] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Butler D]]
[[Category: Cho YJ]]