View source for 6wcb


==Human open state TMEM175 in CsCl==
<StructureSection load='6wcb' size='340' side='right'caption='[[6wcb]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6wcb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WCB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wcb OCA], [https://pdbe.org/6wcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wcb RCSB], [https://www.ebi.ac.uk/pdbsum/6wcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wcb ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. TMEM175 defects result in unstable lysosomal pH, leading to decreased lysosomal catalytic activity, decreased glucocerebrosidase activity, impaired autophagosome clearance by the lysosome and decreased mitochondrial respiration (PubMed:28193887).<ref>PMID:28193887</ref> 
== Function ==
[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.<ref>PMID:26317472</ref> <ref>PMID:28723891</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hite RK]]
[[Category: Oh S]]
[[Category: Paknejad N]]