View source for 6wcq


==Structure of a substrate-bound DQC ubiquitin ligase==
<StructureSection load='6wcq' size='340' side='right'caption='[[6wcq]], [[Resolution|resolution]] 8.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6wcq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WCQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wcq OCA], [https://pdbe.org/6wcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wcq RCSB], [https://www.ebi.ac.uk/pdbsum/6wcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wcq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref> 

==See Also==
*[[Cullin 3D structures|Cullin 3D structures]]
*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Akopian D]]
[[Category: Gee CL]]
[[Category: Greber BJ]]
[[Category: Jevtic P]]
[[Category: Kuriyan J]]
[[Category: Lew BG]]
[[Category: Mena EL]]
[[Category: Nogales E]]
[[Category: Rape M]]