View source for 6wep


==Crystal structure of TS-DHFR from Cryptosporidium hominis with Apo-TS site==
<StructureSection load='6wep' size='340' side='right'caption='[[6wep]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6wep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WEP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wep OCA], [https://pdbe.org/6wep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wep RCSB], [https://www.ebi.ac.uk/pdbsum/6wep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wep ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0S4TER9_CRYHO A0A0S4TER9_CRYHO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]

==See Also==
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
__TOC__
</StructureSection>
[[Category: Cryptosporidium hominis]]
[[Category: Large Structures]]
[[Category: Anderson KS]]
[[Category: Czyzyk DJ]]
[[Category: Jorgensen WL]]
[[Category: Kumar VP]]
[[Category: Ruiz VG]]