View source for 6wr4


==Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery==
<StructureSection load='6wr4' size='340' side='right'caption='[[6wr4]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6wr4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WR4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wr4 OCA], [https://pdbe.org/6wr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wr4 RCSB], [https://www.ebi.ac.uk/pdbsum/6wr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wr4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATG9A_HUMAN ATG9A_HUMAN] Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.<ref>PMID:16940348</ref> 

==See Also==
*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Banerjee A]]
[[Category: Bonifacino JS]]
[[Category: Christenson ET]]
[[Category: Faraldo-Gomez JD]]
[[Category: Guardia CM]]
[[Category: Jiang J]]
[[Category: Lian T]]
[[Category: Lowry AJ]]
[[Category: Rana MS]]
[[Category: Tan X]]
[[Category: Zhou W]]