View source for 6wwd


==Crystal structure of Nucleoside-triphosphatase / dITP/XTP pyrophosphatase from Mycobacterium abscessus ATCC 19977 / DSM 44196==
<StructureSection load='6wwd' size='340' side='right'caption='[[6wwd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6wwd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacteroides_abscessus_ATCC_19977 Mycobacteroides abscessus ATCC 19977]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WWD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wwd OCA], [https://pdbe.org/6wwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wwd RCSB], [https://www.ebi.ac.uk/pdbsum/6wwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wwd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IXTPA_MYCA9 IXTPA_MYCA9] Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacteroides abscessus ATCC 19977]]