View source for 6xkj


==Cryo-EM structure of CARD8-CARD filament==
<StructureSection load='6xkj' size='340' side='right'caption='[[6xkj]], [[Resolution|resolution]] 3.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6xkj]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XKJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.54&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xkj OCA], [https://pdbe.org/6xkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xkj RCSB], [https://www.ebi.ac.uk/pdbsum/6xkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xkj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CARD8_HUMAN CARD8_HUMAN] Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

==See Also==
*[[Caspase 3D structures|Caspase 3D structures]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: David L]]
[[Category: Fontana P]]
[[Category: Fu T]]
[[Category: Hollingsworth LR]]
[[Category: Li Y]]
[[Category: Sharif H]]
[[Category: Wu H]]