View source for 6xor


==Structure of the Self-Association Domain of Swallow==
<StructureSection load='6xor' size='340' side='right'caption='[[6xor]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6xor]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XOR FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xor OCA], [https://pdbe.org/6xor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xor RCSB], [https://www.ebi.ac.uk/pdbsum/6xor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xor ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SWA_DROME SWA_DROME] Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.<ref>PMID:1806330</ref> 
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== Publication Abstract from PubMed ==
Swallow, a 62 kDa multidomain protein, is required for the proper localization of several mRNAs involved in the development of Drosophila oocytes. The dimerization of Swallow depends on a 71-residue self-association domain in the center of the protein sequence, and is significantly stabilized by a binding interaction with dynein light chain (LC8). Here, we detail the use of solution-state nuclear magnetic resonance spectroscopy to characterize the structure of this self-association domain, thereby establishing that this domain forms a parallel coiled-coil and providing insight into how the stability of the dimerization interaction is regulated.

Structural characterization of the self-association domain of swallow.,Loening NM, Barbar E Protein Sci. 2021 Feb 27. doi: 10.1002/pro.4055. PMID:33641207<ref>PMID:33641207</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6xor" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Barbar E]]
[[Category: Loening NM]]