View source for 6yie


==Structure of a Borealin-INCENP-Survivin complex==
<StructureSection load='6yie' size='340' side='right'caption='[[6yie]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6yie]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YIE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.49&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yie OCA], [https://pdbe.org/6yie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yie RCSB], [https://www.ebi.ac.uk/pdbsum/6yie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yie ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INCE_HUMAN INCE_HUMAN] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.<ref>PMID:15316025</ref> <ref>PMID:12925766</ref> <ref>PMID:16760428</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Aurora B chromosomal passenger complex (CPC) is a conserved regulator of mitosis. Its functions require localization first to the chromosome arms and then centromeres in mitosis and subsequently the central spindle in anaphase. Here, we analyze the requirements for core CPC subunits, survivin and INCENP, and the mitotic kinesin-like protein 2 (MKLP2) in targeting to these distinct localizations. Centromere recruitment of the CPC requires interaction of survivin with histone H3 phosphorylated at threonine 3, and we provide a complete structure of this assembly. Furthermore, we show that the INCENP RRKKRR-motif is required for both centromeric localization of the CPC in metaphase and MKLP2-dependent transport in anaphase. MKLP2 and DNA bind competitively to this motif, and INCENP T59 phosphorylation acts as a switch preventing MKLP2 binding in metaphase. In anaphase, CPC binding promotes the microtubule-dependent ATPase activity of MKLP2. These results explain how centromere targeting of the CPC in mitosis is coupled to its movement to the central spindle in anaphase.

Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle.,Serena M, Bastos RN, Elliott PR, Barr FA J Cell Biol. 2020 Jul 6;219(7). pii: 151730. doi: 10.1083/jcb.201910059. PMID:32356865<ref>PMID:32356865</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6yie" style="background-color:#fffaf0;"></div>

==See Also==
*[[Borealin|Borealin]]
*[[Centromere protein 3D structure|Centromere protein 3D structure]]
*[[Survivin|Survivin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barr FA]]
[[Category: Elliott PR]]
[[Category: Serena M]]