View source for 6yjk


==Structure of CYRI-B (FAM49B) from Rhincodon typus==
<StructureSection load='6yjk' size='340' side='right'caption='[[6yjk]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6yjk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhincodon_typus Rhincodon typus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YJK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yjk OCA], [https://pdbe.org/6yjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yjk RCSB], [https://www.ebi.ac.uk/pdbsum/6yjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yjk ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In eukaryotes, numerous fundamental processes are controlled by the WAVE regulatory complex (WRC) that regulates cellular actin polymerization, crucial for cell motility, cell-cell adhesion and epithelial differentiation. Actin assembly is triggered by interaction of the small GTPase Rac1 with CYFIP1, a key component of the WRC. Previously known as FAM49B, CYRI-B is a protein that is highly conserved across the Eukaryota and has recently been revealed to be a key regulator of Rac1 activity. Mutation of CYRI-B or alteration of its expression therefore leads to altered actin nucleation dynamics, with impacts on lamellipodia formation, cell migration and infection by intracellular pathogens. In addition, knockdown of CYRI-B expression in cancer cell lines results in accelerated cell proliferation and invasiveness. Here, the structure of Rhincodon typus (whale shark) CYRI-B is presented, which is the first to be reported of any CYRI family member. Solved by X-ray crystallography, the structure reveals that CYRI-B comprises three distinct alpha-helical subdomains and is highly structurally related to a conserved domain present in CYFIP proteins. The work presented here establishes a template towards a better understanding of CYRI-B biological function.

Structure of CYRI-B (FAM49B), a key regulator of cellular actin assembly.,Kaplan E, Stone R, Hume PJ, Greene NP, Koronakis V Acta Crystallogr D Struct Biol. 2020 Oct 1;76(Pt 10):1015-1024. doi:, 10.1107/S2059798320010906. Epub 2020 Sep 23. PMID:33021503<ref>PMID:33021503</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6yjk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Rhincodon typus]]
[[Category: Kaplan E]]