View source for 6ypt


==X-ray structure of Turnip Yellow Mosaic Virus PRO/DUB in complex with Ubiquitin==
<StructureSection load='6ypt' size='340' side='right'caption='[[6ypt]], [[Resolution|resolution]] 3.66&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ypt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Turnip_yellow_mosaic_virus Turnip yellow mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YPT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.663&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ypt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ypt OCA], [https://pdbe.org/6ypt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ypt RCSB], [https://www.ebi.ac.uk/pdbsum/6ypt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ypt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POLR_TYMV POLR_TYMV] Acts as a cysteine protease, methyltransferase and deubiquitinase. The cyteine protease activity cleaves the polyprotein giving rise to mature proteins. The methyltransferase domain is probably involved in viral RNA capping. The deubiquitylating activity counteracts the degradation of the viral polymerase mediated by the host ubiquitin-proteasome system. The polymerase is thus stabilized and infectivity is increased.<ref>PMID:22117220</ref>   RNA-directed RNA polymerase is responsible for the replication and transcription of the genome.<ref>PMID:22117220</ref> 

==See Also==
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Turnip yellow mosaic virus]]
[[Category: Bressanelli S]]
[[Category: Fieulaine S]]