View source for 6yym


==Structure of S. pombe Mei2 RRM3 domain bound to RNA==
<StructureSection load='6yym' size='340' side='right'caption='[[6yym]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6yym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] and [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YYM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yym OCA], [https://pdbe.org/6yym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yym RCSB], [https://www.ebi.ac.uk/pdbsum/6yym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yym ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MEI2_SCHPO MEI2_SCHPO] Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Long non-coding RNAs (lncRNAs) contribute to the regulation of gene expression in response to intra- or extracellular signals but the underlying molecular mechanisms remain largely unexplored. Here, we identify an uncharacterized lncRNA as a central player in shaping the meiotic gene expression program in fission yeast. We report that this regulatory RNA, termed mamRNA, scaffolds the antagonistic RNA-binding proteins Mmi1 and Mei2 to ensure their reciprocal inhibition and fine tune meiotic mRNA degradation during mitotic growth. Mechanistically, mamRNA allows Mmi1 to target Mei2 for ubiquitin-mediated downregulation, and conversely enables accumulating Mei2 to impede Mmi1 activity, thereby reinforcing the mitosis to meiosis switch. These regulations also occur within a unique Mmi1-containing nuclear body, positioning mamRNA as a spatially-confined sensor of Mei2 levels. Our results thus provide a mechanistic basis for the mutual control of gametogenesis effectors and further expand our vision of the regulatory potential of lncRNAs.

A scaffold lncRNA shapes the mitosis to meiosis switch.,Andric V, Nevers A, Hazra D, Auxilien S, Menant A, Graille M, Palancade B, Rougemaille M Nat Commun. 2021 Feb 3;12(1):770. doi: 10.1038/s41467-021-21032-7. PMID:33536434<ref>PMID:33536434</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6yym" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Graille M]]
[[Category: Hazra D]]