View source for 6zbz


==Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling==
<StructureSection load='6zbz' size='340' side='right'caption='[[6zbz]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6zbz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZBZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QE5:2-[(3,4-dimethylphenyl)sulfonylamino]-5-fluoranyl-benzoic+acid'>QE5</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zbz OCA], [https://pdbe.org/6zbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zbz RCSB], [https://www.ebi.ac.uk/pdbsum/6zbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zbz ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Heinemann U]]
[[Category: Oschkinat H]]
[[Category: Roske Y]]