View source for 6zc3


==Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling==
<StructureSection load='6zc3' size='340' side='right'caption='[[6zc3]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6zc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JOR:5-fluoranyl-2-(methylsulfonylamino)benzoic+acid'>JOR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc3 OCA], [https://pdbe.org/6zc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc3 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc3 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Heinemann U]]
[[Category: Oschkinat H]]
[[Category: Roske Y]]