View source for 6zsz


==Crystal structure of the Grindelwald extracellular domain complex==
<StructureSection load='6zsz' size='340' side='right'caption='[[6zsz]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6zsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZSZ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">grnd, CG10176 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zsz OCA], [https://pdbe.org/6zsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zsz RCSB], [https://www.ebi.ac.uk/pdbsum/6zsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zsz ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/GRND_DROME GRND_DROME]] Acts as a receptor for egr. Plays a role in activation of JNK signaling and is required for egr-induced apoptosis. May also play an egr-independent role in cell proliferation.<ref>PMID:25874673</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Drosophila tumour necrosis factor (TNF) ligand-receptor system consists of a unique ligand, Eiger (Egr), and two receptors, Grindelwald (Grnd) and Wengen (Wgn), and therefore provides a simple system for exploring the interplay between ligand and receptors, and the requirement for Grnd and Wgn in TNF/Egr-mediated processes. Here, we report the crystallographic structure of the extracellular domain (ECD) of Grnd in complex with Egr, a high-affinity hetero-hexameric assembly reminiscent of human TNF:TNFR complexes. We show that ectopic expression of Egr results in internalisation of Egr:Grnd complexes in vesicles, a step preceding and strictly required for Egr-induced apoptosis. We further demonstrate that Wgn binds Egr with much reduced affinity and is localised in intracellular vesicles that are distinct from those containing Egr:Grnd complexes. Altogether, our data provide insight into ligand-mediated activation of Grnd and suggest that distinct affinities of TNF ligands for their receptors promote different and non-redundant cellular functions.

Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.,Palmerini V, Monzani S, Laurichesse Q, Loudhaief R, Mari S, Cecatiello V, Olieric V, Pasqualato S, Colombani J, Andersen DS, Mapelli M Nat Commun. 2021 Apr 6;12(1):2070. doi: 10.1038/s41467-021-22080-9. PMID:33824334<ref>PMID:33824334</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6zsz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drome]]
[[Category: Large Structures]]
[[Category: Cecatiello, V]]
[[Category: Mapelli, M]]
[[Category: Palmerini, V]]
[[Category: Pasqualato, S]]
[[Category: Extracellular]]
[[Category: Jnk cascade]]
[[Category: Signaling]]
[[Category: Signaling protein]]
[[Category: Tnf]]
[[Category: Tnf receptor]]
[[Category: Tumor necrosis factor]]