View source for 6zxk


==Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement==
<StructureSection load='6zxk' size='340' side='right'caption='[[6zxk]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6zxk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZXK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zxk OCA], [https://pdbe.org/6zxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zxk RCSB], [https://www.ebi.ac.uk/pdbsum/6zxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zxk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.

==See Also==
*[[Anthrax lethal factor 3D structures|Anthrax lethal factor 3D structures]]
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</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Large Structures]]
[[Category: Antoni C]]
[[Category: Gatsogiannis C]]
[[Category: Quentin D]]
[[Category: Raunser S]]