View source for 7aam


==Crystal structure of the F-BAR domain of PSTIPIP1 bound to the CTH domain of the phosphatase LYP==
<StructureSection load='7aam' size='340' side='right'caption='[[7aam]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7aam]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AAM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aam OCA], [https://pdbe.org/7aam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aam RCSB], [https://www.ebi.ac.uk/pdbsum/7aam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aam ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PPIP1_HUMAN PPIP1_HUMAN] Defects in PSTPIP1 are the cause of PAPA syndrome (PAPAS) [MIM:[https://omim.org/entry/604416 604416]; also known as pyogenic sterile arthritis, pyoderma gangrenosum and acne or familial recurrent arthritis (FRA). PAPAS is characterized by autosomal dominant inheritance of early onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction.<ref>PMID:14595024</ref> <ref>PMID:11971877</ref> 
== Function ==
[https://www.uniprot.org/uniprot/PPIP1_HUMAN PPIP1_HUMAN] Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2.<ref>PMID:9857189</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alcon P]]
[[Category: Alonso A]]
[[Category: Bayon Y]]
[[Category: Manso JA]]
[[Category: De Pereda JM]]