View source for 7afr


==Ribosome maturation factor RimP (apo)==
<StructureSection load='7afr' size='340' side='right'caption='[[7afr]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AFR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7afr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7afr OCA], [https://pdbe.org/7afr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7afr RCSB], [https://www.ebi.ac.uk/pdbsum/7afr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7afr ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
While a structural description of the molecular mechanisms guiding ribosome assembly in eukaryotic systems is emerging, bacteria use an unrelated core set of assembly factors for which high-resolution structural information is still missing. To address this, we used single-particle cryo-electron microscopy to visualize the effects of bacterial ribosome assembly factors RimP, RbfA, RsmA, and RsgA on the conformational landscape of the 30S ribosomal subunit and obtained eight snapshots representing late steps in the folding of the decoding center. Analysis of these structures identifies a conserved secondary structure switch in the 16S ribosomal RNA central to decoding site maturation and suggests both a sequential order of action and molecular mechanisms for the assembly factors in coordinating and controlling this switch. Structural and mechanistic parallels between bacterial and eukaryotic systems indicate common folding features inherent to all ribosomes.

A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.,Schedlbauer A, Iturrioz I, Ochoa-Lizarralde B, Diercks T, Lopez-Alonso JP, Lavin JL, Kaminishi T, Capuni R, Dhimole N, de Astigarraga E, Gil-Carton D, Fucini P, Connell SR Sci Adv. 2021 Jun 4;7(23). pii: 7/23/eabf7547. doi: 10.1126/sciadv.abf7547. Print, 2021 Jun. PMID:34088665<ref>PMID:34088665</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Connell S]]
[[Category: Diercks T]]
[[Category: Fucini P]]
[[Category: Iturrioz I]]
[[Category: Ochoa-Lizarralde B]]
[[Category: Schedlbauer A]]