View source for 7ale


==Crystal structure of human PAICS in complex with inhibitor 69==
<StructureSection load='7ale' size='340' side='right'caption='[[7ale]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ale]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ALE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ALE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OK8:(2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car+bonylamino]butanedioic+acid'>OK8</scene>, <scene name='pdbligand=RLK:2-azanyl-~{N}-[2-bromanyl-5-[4-[3-(dimethylamino)propylsulfonyl]piperazin-1-yl]phenyl]-1,3-oxazole-4-carboxamide'>RLK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ale FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ale OCA], [https://pdbe.org/7ale PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ale RCSB], [https://www.ebi.ac.uk/pdbsum/7ale PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ale ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PUR6_HUMAN PUR6_HUMAN] 
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Grube M]]
[[Category: Helleday T]]
[[Category: Henriksson M]]
[[Category: Homan E]]
[[Category: Jemth A-S]]
[[Category: Marttila P]]
[[Category: Skerlova J]]
[[Category: Stenmark P]]
[[Category: Unterlass J]]
[[Category: Wakchaure P]]
[[Category: Warpman Berglund U]]