View source for 7apk


==Structure of the human THO - UAP56 complex==
<StructureSection load='7apk' size='340' side='right'caption='[[7apk]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7apk]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7APK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7APK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7apk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7apk OCA], [https://pdbe.org/7apk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7apk RCSB], [https://www.ebi.ac.uk/pdbsum/7apk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7apk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THOC1_HUMAN THOC1_HUMAN] Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4.<ref>PMID:10512864</ref> <ref>PMID:10840029</ref> <ref>PMID:11050087</ref> <ref>PMID:11979277</ref> <ref>PMID:15833825</ref> <ref>PMID:15998806</ref> <ref>PMID:15870275</ref> <ref>PMID:17190602</ref> <ref>PMID:18974867</ref>   Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.<ref>PMID:10512864</ref> <ref>PMID:10840029</ref> <ref>PMID:11050087</ref> <ref>PMID:11979277</ref> <ref>PMID:15833825</ref> <ref>PMID:15998806</ref> <ref>PMID:15870275</ref> <ref>PMID:17190602</ref> <ref>PMID:18974867</ref> 

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hohmann U]]
[[Category: Plaschka C]]
[[Category: Puehringer T]]