View source for 7apx


==yeast THO-Sub2 complex==
<StructureSection load='7apx' size='340' side='right'caption='[[7apx]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7apx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7APX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7APX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7apx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7apx OCA], [https://pdbe.org/7apx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7apx RCSB], [https://www.ebi.ac.uk/pdbsum/7apx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7apx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MFT1_YEAST MFT1_YEAST] Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.<ref>PMID:12093753</ref> <ref>PMID:12871933</ref> <ref>PMID:14527416</ref> <ref>PMID:15192704</ref> 

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Baumgartner M]]
[[Category: Bonneau F]]
[[Category: Conti E]]
[[Category: Prabu RJ]]
[[Category: Schuller JM]]
[[Category: Schuller SK]]
[[Category: Basquin J]]