View source for 7aqo


==yeast THO-Sub2 complex dimer==
<StructureSection load='7aqo' size='340' side='right'caption='[[7aqo]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7aqo]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AQO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aqo OCA], [https://pdbe.org/7aqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aqo RCSB], [https://www.ebi.ac.uk/pdbsum/7aqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aqo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THO2_YEAST THO2_YEAST] Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.<ref>PMID:12093753</ref> <ref>PMID:12871933</ref> <ref>PMID:14527416</ref> <ref>PMID:15192704</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Baumgartner M]]
[[Category: Bonneau F]]
[[Category: Conti E]]
[[Category: Prabu RJ]]
[[Category: Schuller JM]]
[[Category: Schuller SK]]
[[Category: Basquin J]]