View source for 7ayz


==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with activator TH10785==
<StructureSection load='7ayz' size='340' side='right'caption='[[7ayz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ayz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AYZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SEQ:~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine'>SEQ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ayz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ayz OCA], [https://pdbe.org/7ayz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ayz RCSB], [https://www.ebi.ac.uk/pdbsum/7ayz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ayz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OGG1_MOUSE OGG1_MOUSE] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

==See Also==
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Davies JR]]
[[Category: Masuyer G]]
[[Category: Stenmark P]]