View source for 7blr


==Vps35/Vps29 arch of fungal membrane-assembled retromer:Vps5 (SNX-BAR) complex.==
<StructureSection load='7blr' size='340' side='right'caption='[[7blr]], [[Resolution|resolution]] 9.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7blr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BLR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7blr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7blr OCA], [https://pdbe.org/7blr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7blr RCSB], [https://www.ebi.ac.uk/pdbsum/7blr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7blr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G0S709_CHATD G0S709_CHATD] Plays a role in vesicular protein sorting.[PIRNR:PIRNR009375]
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== Publication Abstract from PubMed ==
Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many cellular processes including signaling, immunity, neuroprotection, and virus infection. The retromer core (VPS26/VPS29/VPS35) is present on cargo-transporting, tubular carriers along with a range of sorting nexins. Here, we elucidate the structural basis of membrane tubulation and coupled cargo recognition by metazoan and fungal retromer coats assembled with the non-Bin1/Amphiphysin/Rvs (BAR) sorting nexin SNX3 using cryo-electron tomography. The retromer core retains its arched, scaffolding structure but changes its mode of membrane recruitment when assembled with different SNX adaptors, allowing cargo recognition at subunit interfaces. Thus, membrane bending and cargo incorporation can be modulated to allow retromer to traffic cargoes along different cellular transport routes.

Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.,Leneva N, Kovtun O, Morado DR, Briggs JAG, Owen DJ Sci Adv. 2021 Mar 24;7(13):eabf8598. doi: 10.1126/sciadv.abf8598. Print 2021 Mar. PMID:33762348<ref>PMID:33762348</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7blr" style="background-color:#fffaf0;"></div>

==See Also==
*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
[[Category: Large Structures]]
[[Category: Briggs JAG]]
[[Category: Kovtun O]]
[[Category: Leneva N]]
[[Category: Morado DR]]
[[Category: Owen DJ]]