View source for 7bml


==Crystal structure of outer surface protein C (OspC) from Borrelia burgdorferi==
<StructureSection load='7bml' size='340' side='right'caption='[[7bml]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7bml]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BML FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bml OCA], [https://pdbe.org/7bml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bml RCSB], [https://www.ebi.ac.uk/pdbsum/7bml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bml ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OSPC2_BORBG OSPC2_BORBG] Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.[UniProtKB:Q07337]

==See Also==
*[[Outer surface protein|Outer surface protein]]
__TOC__
</StructureSection>
[[Category: Borreliella burgdorferi]]
[[Category: Large Structures]]
[[Category: Bierwagen P]]
[[Category: Jaskolski M]]
[[Category: Ruszkowski M]]
[[Category: Sliwiak J]]
[[Category: Urbanowicz A]]