View source for 7bqi


==Crystal structure of FYCO1 RUN domain==
<StructureSection load='7bqi' size='340' side='right'caption='[[7bqi]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7bqi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BQI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bqi OCA], [https://pdbe.org/7bqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bqi RCSB], [https://www.ebi.ac.uk/pdbsum/7bqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bqi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FYCO1_HUMAN FYCO1_HUMAN] Nuclear cataract. The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).<ref>PMID:21636066</ref> 
== Function ==
[https://www.uniprot.org/uniprot/FYCO1_HUMAN FYCO1_HUMAN] May mediate microtubule plus end-directed vesicle transport.<ref>PMID:20100911</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ohto U]]
[[Category: Sakurai S]]
[[Category: Shimizu T]]