View source for 7br9


==Crystal structure of mus musculus IRG1==
<StructureSection load='7br9' size='340' side='right'caption='[[7br9]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7br9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BR9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7br9 OCA], [https://pdbe.org/7br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7br9 RCSB], [https://www.ebi.ac.uk/pdbsum/7br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7br9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRG1_MOUSE IRG1_MOUSE] Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:30635240, PubMed:31548418). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). Plays a role in the embryo implantation (PubMed:14500577).<ref>PMID:14500577</ref> <ref>PMID:23609450</ref> <ref>PMID:23610393</ref> <ref>PMID:30635240</ref> <ref>PMID:31548418</ref> <ref>PMID:35662396</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
PROTEIN DATA BANK ACCESSION CODES: Coordinate and structural factors were deposited with the Protein Data Bank under PDB ID: 7BR9.

The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation.,Chun HL, Lee SY, Kim KH, Lee CS, Oh TJ, Park HH PLoS One. 2020 Dec 1;15(12):e0242383. doi: 10.1371/journal.pone.0242383., eCollection 2020. PMID:33259501<ref>PMID:33259501</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7br9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Chun HL]]
[[Category: Park HH]]