View source for 7bzn


==Cryo-EM structure of mature Coxsackievirus A10 at pH 7.4==
<StructureSection load='7bzn' size='340' side='right'caption='[[7bzn]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7bzn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A10 Coxsackievirus A10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BZN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bzn OCA], [https://pdbe.org/7bzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bzn RCSB], [https://www.ebi.ac.uk/pdbsum/7bzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bzn ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
KREMEN1 (KRM1) has been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD), which poses a great threat to infants globally. However, the underlying mechanisms for the viral entry process are not well understood. Here we determined the atomic structures of different forms of CV-A10 viral particles and its complex with KRM1 in both neutral and acidic conditions. These structures reveal that KRM1 selectively binds to the mature viral particle above the canyon of the viral protein 1 (VP1) subunit and contacts across two adjacent asymmetry units. The key residues for receptor binding are conserved among most KRM1-dependent enteroviruses, suggesting a uniform mechanism for receptor binding. Moreover, the binding of KRM1 induces the release of pocket factor, a process accelerated under acidic conditions. Further biochemical studies confirmed that receptor binding at acidic pH enabled CV-A10 virion uncoating in vitro. Taken together, these findings provide high-resolution snapshots of CV-A10 entry and identify KRM1 as a two-in-one receptor for enterovirus infection.

Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1.,Cui Y, Peng R, Song H, Tong Z, Qu X, Liu S, Zhao X, Chai Y, Wang P, Gao GF, Qi J Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18711-18718. doi:, 10.1073/pnas.2005341117. Epub 2020 Jul 20. PMID:32690697<ref>PMID:32690697</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 7bzn" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Coxsackievirus A10]]
[[Category: Large Structures]]
[[Category: Cui Y]]
[[Category: Gao GF]]
[[Category: Peng R]]
[[Category: Qi J]]
[[Category: Song H]]
[[Category: Tong Z]]