View source for 7cbl


==Cryo-EM structure of the flagellar LP ring from Salmonella==
<StructureSection load='7cbl' size='340' side='right'caption='[[7cbl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7cbl]] is a 52 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CBL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCA:OCTANOIC+ACID+(CAPRYLIC+ACID)'>OCA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cbl OCA], [https://pdbe.org/7cbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cbl RCSB], [https://www.ebi.ac.uk/pdbsum/7cbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cbl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FLGH_SALTY FLGH_SALTY] Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The bacterial flagellar motor is a supramolecular protein machine that drives rotation of the flagellum for motility, which is essential for bacterial survival in different environments and a key determinant of pathogenicity. The detailed structure of the flagellar motor remains unknown. Here we present an atomic-resolution cryoelectron microscopy (cryo-EM) structure of the bacterial flagellar motor complexed with the hook, consisting of 175 subunits with a molecular mass of approximately 6.3 MDa. The structure reveals that 10 peptides protruding from the MS ring with the FlgB and FliE subunits mediate torque transmission from the MS ring to the rod and overcome the symmetry mismatch between the rotational and helical structures in the motor. The LP ring contacts the distal rod and applies electrostatic forces to support its rotation and torque transmission to the hook. This work provides detailed molecular insights into the structure, assembly, and torque transmission mechanisms of the flagellar motor.

Structural basis of assembly and torque transmission of the bacterial flagellar motor.,Tan J, Zhang X, Wang X, Xu C, Chang S, Wu H, Wang T, Liang H, Gao H, Zhou Y, Zhu Y Cell. 2021 Apr 14. pii: S0092-8674(21)00430-X. doi: 10.1016/j.cell.2021.03.057. PMID:33882274<ref>PMID:33882274</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7cbl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Chang SH]]
[[Category: Tan JX]]
[[Category: Wang XF]]
[[Category: Xu CH]]
[[Category: Zhang X]]
[[Category: Zhou Y]]
[[Category: Zhu YQ]]