View source for 7cbo


==Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc==
<StructureSection load='7cbo' size='340' side='right'caption='[[7cbo]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7cbo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Akkermansia_muciniphila_ATCC_BAA-835 Akkermansia muciniphila ATCC BAA-835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CBO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cbo OCA], [https://pdbe.org/7cbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cbo RCSB], [https://www.ebi.ac.uk/pdbsum/7cbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cbo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H0868_AKKM8 H0868_AKKM8] Potentially capable of cleaving the specific glycoside linkages in the process of mucin degradation in human intestinal tract (Probable). Hydrolyzes chromogenic substrates pNP-beta-GlcNAc with high activity and pNP-beta-GalNAc to a lesser extent, but not pNP-beta-glucose or pNP-beta-galactose (PubMed:32819592).<ref>PMID:32819592</ref> 

==See Also==
*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Akkermansia muciniphila ATCC BAA-835]]
[[Category: Large Structures]]
[[Category: Wang M]]
[[Category: Xu W]]
[[Category: Zhang M]]