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==Structure of the CBS domain of the CorC Mg2+ transporter in complex with ATP==
<StructureSection load='7cfi' size='340' side='right'caption='[[7cfi]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CFI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cfi OCA], [https://pdbe.org/7cfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cfi RCSB], [https://www.ebi.ac.uk/pdbsum/7cfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cfi ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The CNNM/CorC family proteins are Mg(2+) transporters that are widely distributed in all domains of life. In bacteria, CorC has been implicated in the survival of pathogenic microorganisms. In humans, CNNM proteins are involved in various biological events, such as body absorption/reabsorption of Mg(2+) and genetic disorders. Here, we determined the crystal structure of the Mg(2+)-bound CorC TM domain dimer. Each protomer has a single Mg(2+) binding site with a fully dehydrated Mg(2+) ion. The residues at the Mg(2+) binding site are strictly conserved in both human CNNM2 and CNNM4, and many of these residues are associated with genetic diseases. Furthermore, we determined the structures of the CorC cytoplasmic region containing its regulatory ATP-binding domain. A combination of structural and functional analyses not only revealed the potential interface between the TM and cytoplasmic domains but also showed that ATP binding is important for the Mg(2+) export activity of CorC.

Structural basis for the Mg(2+) recognition and regulation of the CorC Mg(2+) transporter.,Huang Y, Jin F, Funato Y, Xu Z, Zhu W, Wang J, Sun M, Zhao Y, Yu Y, Miki H, Hattori M Sci Adv. 2021 Feb 10;7(7). pii: 7/7/eabe6140. doi: 10.1126/sciadv.abe6140. Print , 2021 Feb. PMID:33568487<ref>PMID:33568487</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 7cfi" style="background-color:#fffaf0;"></div>

==See Also==
*[[Hemolysin 3D structures|Hemolysin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Hattori M]]
[[Category: Huang Y]]
[[Category: Jin F]]